Study Links Hodgkin Lymphoma Treatment to Possible Risk of Stomach Cancer
Bethesda, MD - Hodgkin lymphoma survivors who received certain radiation and chemotherapy regimens were at increased risk of subsequently developing stomach cancer, according to a study by scientists at the National Cancer Institute (NCI), part of the National Institutes of Health. The study appeared today in the Journal of Clinical Oncology.
While the cure rate for Hodgkin lymphoma is high, there is a risk of developing secondary malignancies, such as breast cancer, lung cancer and stomach cancer. Past studies have linked Hodgkin lymphoma radiation and chemotherapy treatments with stomach cancer risk, but those studies have been limited in scope. To better understand the relationship between Hodgkin lymphoma treatments and subsequent stomach cancer risk, Lindsay M. Morton, Ph.D., NCI Division of Cancer Epidemiology and Genetics, and her colleagues analyzed data from the Netherlands, Denmark, Finland, Norway, Sweden, the United States and Canada. Their analyses included nearly 20,000 survivors of the disease who were diagnosed between 1953 and 2003.
Of 17,477 Hodgkin lymphoma cases examined, the researchers identified 89 survivors who later developed stomach cancer. From patient medical records, they obtained detailed information on treatments, which they used to estimate radiation doses to the stomach and to calculate the doses and types of chemotherapy that were used to treat the survivors’ Hodgkin lymphoma. By comparing the treatments received by the survivors who developed stomach cancer with the treatments received by survivors who did not develop stomach cancer, the investigators were able to determine the risks of developing stomach cancer from the treatment for Hodgkin lymphoma. Continue>
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