Scientists Identify Key Predictors of Death and Transplantation in Children with Heart Muscle Disease
Miami, FL - US scientists have identified key risk factors that predict which children with hypertrophic cardiomyopathy, the most common cause of sudden death in young people, are at greatest risk of death or need for heart transplant — information that could help physicians figure out who will benefit most from transplant surgery.
"If we knew who was in the gravest danger from this condition, we could evaluate them for early listing for heart transplant and follow them more closely,” explains study leader Professor Steven E Lipshultz, Director of the Batchelor Children’s Research Institute from the University of Miami Miller School of Medicine in Florida, in The Lancet.
“Now we have identified patient risk factors that can be measured at the time of diagnosis to guide treatment decisions and help newly diagnosed patients and their families have some idea of what to expect from their disease.”
Hypertrophic cardiomyopathy is a serious, potentially fatal, condition that causes the heart muscle to thicken, thus impairing cardiac function and predisposing people to heart failure and sudden death.
Investigators used the Pediatric Cardiomyopathy Registry (PCMR), a database of paediatric cardiomyopathy patients from 98 centres across the USA and Canada diagnosed over a 19-year period. They analysed the clinical and demographic characteristics at the time of diagnosis of 1085 children (18 years of age or younger) and their contribution to the outcomes of death and heart transplantation. Continue>
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