September 26, 2017 |
Simple Test Can Indicate Cervical Cancer (VIDEO)
January 15, 2014  | 

 

Louisville, KY - Researchers at the University of Louisville have confirmed that using the heat profile from a person’s blood, called a plasma thermogram, can serve as an indicator for the presence or absence of cervical cancer, including the stage of cancer.

The team, led by Nichola Garbett, Ph.D., published its findings online in PLOS ONE.

“We have been able to demonstrate a more convenient, less intrusive test for detecting and staging cervical cancer,” Garbett said. “Additionally, other research has shown that we are able to demonstrate if the current treatment is effective so that clinicians will be able to better tailor care for each patient.”

To generate a plasma thermogram, a blood plasma sample is “melted” producing a unique signature indicating a person’s health status. This signature represents the major proteins in blood plasma, measured by Differential Scanning Calorimetry (DSC). The team, which includes Brad Chaires, Ph.D., Ben Jenson, Ph.D., William Helm, M.D., Michael Merchant, Ph.D., and Jon Klein, M.D., Ph.D., from the University of Louisville School of Medicine, have demonstrated that the plasma thermogram profile varies when a person has or does not have the disease. The team believes that molecules associated with the presence of disease, called biomarkers, can affect the thermogram of someone with cervical disease. They used mass spectrometry to show that biomarkers associated with cervical cancer existed in the plasma. Continue>

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