July 24, 2017 |
Clinical Trial Suggests Drug Combo May Be Highly Effective in Recurrent Ovarian Cancer
June 5, 2014  | 

Boston, MA - Significant improvement with the use of a combination drug therapy for recurrent ovarian cancer was reported at the annual meeting of the American Society of Clinical Oncology meeting in Chicago. This is the first ovarian cancer study to use a combination of drugs that could be taken orally. The drugs were tested in a phase I combination study followed by a randomized phase 2 trial sponsored by the National Cancer Institute (NCI), part of the National Institutes of Health.

The trial compared the activity of a combination of the drug olaparib (which blocks DNA repair) and the blood vessel inhibitor drug cediranib, vs. olaparib alone. Trial results showed a near doubling of progression-free survival benefit (the length of time during and after treatment that the cancer did not get worse) for the combination therapy over use of the single drug alone.

“The findings of this study are exciting because they support the idea that combining these two targeted oral therapies results in significant activity in ovarian cancer, more so than olaparib alone,” said Joyce Liu, M.D., M.P.H., the lead investigator and medical oncologist at the Susan F. Smith Center for Women's Cancers at Dana-Farber Cancer Institute, Boston. “We are looking forward to further exploring this combination in ovarian cancer and potentially increasing effective treatment options for our patients with this cancer.” Continue>

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