Statins May Improve Wound Healing Following Cardiac Surgery
Chicago, IL – Statin therapy may help to improve wound healing in patients following cardiac surgery and reduce overall recovery time, especially in patients who are prone to healing complications, according to a review article in the August 2014 issue of The Annals of Thoracic Surgery.
“Statins have become one of the most widely prescribed medications in the world. While they are typically used to manage high cholesterol levels, a number of researchers have been investigating the benefits of statins in other conditions, such as severe infections or following organ transplantation,” said lead author Gerard J. Fitzmaurice, MRCSI, MSc, from Our Lady’s Children’s Hospital in Dublin, Ireland.
Fitzmaurice, Mark E. O’Donnell, MD, and colleagues reviewed existing literature, most of which included laboratory-based studies on animals, and found that statins appear to affect the inflammatory response, thereby reducing the length of time needed to heal following surgery (13.0 days versus 18.7 days) and potentially resulting in smaller scars.
Wounds that may benefit from statin therapy include those resulting from cardiac surgery, such as surgical chest wounds from a sternotomy, leg wounds from a long saphenous vein harvest, or forearm wounds from a radial artery harvest; however the researchers said that any surgical wound could benefit from statins.
“Normal wound healing involves a series of phases that ultimately leads to a scar. Many things can affect this process and it’s difficult to determine exactly how statins might improve wound healing, but it would appear that they influence a number of factors in the inflammatory response,” said Fitzmaurice. “Our analysis also shows that some statins are better at it than others.” Continue>
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