January 23, 2018 |
Proposed Principles and Guidelines for Reporting Preclinical Research
November 5, 2014  | 

Bethesda, MD The signatories represent journals that publish preclinical biological research — an area of research that encompasses both exploratory studies and hypothesis-testing studies, with many different designs. The reproducibility of these studies is expected to vary. The journals agree to adhere to the following principles with the aim of facilitating the interpretation and repetition of experiments as they have been conducted in the published study. These measures and principles do not obviate the need for replication and reproduction in subsequent investigations to establish the robustness of published results across multiple biological systems.

  1. Rigorous statistical analysis

    A section outlining the journal’s policies for statistical analysis should be included in the Information for Authors, and the journal should have a mechanism to check the statistical accuracy of submissions.
  2. Transparency in reporting

    Journals should have no limit or generous limits on the length of methods sections (including online options), while at the same time encouraging efficient and clear presentation to ensure a thorough examination by reviewers.

    Journals should use a checklist during editorial processing to ensure the reporting of key methodological and analytical information to reviewers and readers. (A proposed set of key information is listed below). 

    Core set of standards for rigorous reporting of study design (Adapted from Landis et al.)

    Include these reporting standards in Information for Authors or other public place. Require authors to fill out a checklist, ideally upon submission, to state where the required information is located in the manuscript. Continue>

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