September 24, 2017 |
Chemical Compound Decreases Effects of Multiple Sclerosis
December 3, 2014  | 

Riverside, CA – Given the debilitating effects of Multiple sclerosis (MS), an aggressive search is on among scientists to find a cure. Currently available therapies are only partially effective, however, in preventing the onset of permanent disability in MS patients. What would be immensely helpful is a drug that could minimize the degeneration of axons, thus reducing the rate and degree of MS progression. Better still would be if this drug could stimulate “remyelination,” the re-sheathing of the axons, restoring fast and uninterrupted flow of nerve impulses.

Now a team of researchers, led by a biomedical scientist at the University of California, Riverside, reports in this week’s issue of the Proceedings of the National Academy of Sciences that it has identified just such a drug in the lab: indazole chloride (Ind-Cl).

“This drug, which we administered on transgenic mice, can potentially halt the symptoms and reverse ongoing motor deficit due to MS,” said Seema K. Tiwari-Woodruff, an associate professor in the UC Riverside School of Medicine whose lab led the study. “Our study shows that Ind-Cl can remyelinate axons which have gotten injured not just in MS but also traumatic brain injury and spinal cord injury.” Continue>

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