Potential Link Found Between Low Bone Density and Alzheimer’s
Rootstown, OH — Researchers found a connection between reduced bone mineral density (BMD) and Alzheimer’s disease, according to an article in November’s issue of the Journal of Alzheimer’s Disease. The results suggest that it may be a biomarker for the disease, presenting before significant cognitive decline.
Through their research the group from Northeast Ohio Medical University found that BMD and osteoporosis occur at a much greater rate in patients with Alzheimer’s disease.
While their experiments found the connection they are uncertain of the mechanism responsible. The study hypothesizes however that bone loss is an additional component of an Alzheimer’s prodrome, changes that emerge prior to dementia and are, “mediated by the dysfunction of the central serotonergic pathways.”
Their work in mice also found reduced tryptophan hydroxylase (TPH) protein in htau brainstem and a 70 percent reduction in TPH-positive cells in the dorsal raphe nucleus (DRN) as well as elevated levels of ptau proteins in the brainstem and the presence of ptau in TPH-positive cells of the DRN at as early as 4 months of age.
This connection, according to the authors, highlights the need to clearly define the BMD and Alzheimer’s in the future.
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